KMID : 0620920070390030295
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Experimental & Molecular Medicine 2007 Volume.39 No. 3 p.295 ~ p.303
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gp130 is important for the normal morphogenesis of Meckel¡¯s cartilage and subsequent mandibular development
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Choi Jung-Won
Kim Jung-Tak Park Jae-Han Park Eui-Kyun Kim Shin-Yoon Kwon Tae-Geon Kim Eun-Cheol Shin Hong-In
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Abstract
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gp130-mediated signaling is involved in both chondrogenesis and osteogenesis, but its direct role in the formation of embryonic Meckel¡¯s cartilage and associated mandibular development has not yet been elucidated. In this study, we examined the influence of gp130 ablation on the developing mandibular Meckel¡¯s cartilage by evaluating the morphological and histological changes as well as the gene expression patterns in developing embryonic gp130-/- mice. The ablation of the gp130 gene showed no change in region-specific collagen mRNA expression except for a slight delay in its expression but caused shortened embryonic Meckel¡¯s cartilage, delayed hypertrophic chondrocyte maturation and subsequent bony replacement with characteristic bending of the intramandibular Meckel¡¯s cartilage. The bending of Meckel¡¯s cartilage led to a narrow mandibular arch at the rostral area with poor cortical plate formation. These findings indicate that gp130-mediated signaling is important for the normal morphogenesis of Meckel¡¯s cartilage and subsequent mandibular development.
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KEYWORD
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cartilage, cytokine receptor gp130, chondrogenesis, in situ hybridization, mandible, morphogenesis
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